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title: Pharmaceutical Freeze Drying
description: Pharmaceutical Freeze Drying
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# Pharmaceutical Freeze Drying
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- Pharmaceutical Freeze Drying
[Blair Kibblewhite](https://info.cuddonfreezedry.com/blog/author/blair-kibblewhite) 06/17/2015
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The freeze drying process has important applications in the pharmaceutical and biotechnology industries, and pharmaceutical freeze drying is now a standard process used to stabilise, store or increase the shelf life of drug products and other biologicals.
**Pharmaceutical Freeze Drying Process**
Freeze drying pharmaceuticals uses a process called lyophilization to lower the temperature of the product to below freezing, and then a high-pressure vacuum is applied to extract the water in the form of vapour. The vapour collects on a condenser, turns back to ice and is removed. Finally, a gradual temperature rise extracts all remaining 'bound' moisture from the product. This process retains the physical structure and preserves the material for storage or transport.
**Advantages of Freeze Drying Pharmaceuticals**
With freeze drying, delicate, unstable or heat-sensitive drugs and biologicals can be dried at low temperatures without damaging their physical structure. Freeze-dried products can be reconstituted quickly and easily, which is particularly valuable in the case of emergency vaccines and antibodies, which need to be administered as quickly as possible.
**Freezing alone has some major disadvantages:**
- Maintaining frozen storage is costly and takes up a lot of space
- Transportation of frozen materials can be difficult and expensive
- Failure of freezing equipment would risk the total loss of the product
Conventional drying methods also have a major disadvantage as the high temperatures used can cause chemical or physical changes to the product. For pharmaceuticals and bio-products, this would cause a reduction in biological activity, which could render them ineffective.
**Pharmaceuticals and Biologicals Suitable For Freeze Drying**
- Vaccines and antibodies
- Penicillin
- Blood plasma
- Proteins
- Enzymes
- Hormones
- Viruses and bacteria
Cuddon designs and manufactures freeze drying machines for sale worldwide.
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